Abstract
The present study was conducted to explore the effects of hellgrammites protein hydrocortisone administration induced Kidney-Yang Deficiency syndrome (KYDS) rats. The proteins were extracted from hellgrammites. Protein content was determined by Kjeldahl method. 51 rats were divided randomly into 5 groups. (group 1: blank control; group 2: KYDS model; group 3: KYDS rats treated with desmopressin(DDAVP); group 4: KYDS rats treated with hellgrammites protein low dose group 100 mg/kg; group 5: KYDS rats treated with hellgrammites protein high dose group 200 mg/kg). The rats were injected intraperitoneally hydrocortisone once daily for 18 days to simulate ‘Kidney-Yang Deficiency syndrome’, then the ninth day administered orally hellgrammites protein extract once daily for the following 12 days. The ALD, AVP, CAMP, CAMP/CGMP and renal tissue expression in different groups were compared. Compared with blank control diet group, CAMP/CGMP in hyperlipemia model group decreased ( P < 0. 05) and increased ALD(P ＞0.05). After treatment with hellgrammites protein high dose group and DDAVP group, CAMP/CGMP of the Kidney yang deficiency rats increased (P< 0. 05) and increased ALD(P＜0. 05). The hellgrammites protein extract have protective effects on the rat model of kidney yang deficiency and polyuria caused by hydrocortisone.
Highlights
‘Kidney-Yang Deficiency syndrome’ is one of the elementary syndrome patterns in traditional Chinese medicine and closely related to multiple disordered metabolic pathway(s F. Gao et al, 2006)
There has not research on the relationship between hellgrammite protein and kidney yang deficiency syndrome
We explored the effect of hellgrammite proteins on kidney yang deficiency syndrome
Summary
‘Kidney-Yang Deficiency syndrome’ is one of the elementary syndrome patterns in traditional Chinese medicine and closely related to multiple disordered metabolic pathway(s F. Gao et al, 2006). This model has been widely employed in the evaluation of therapeutic effect and action mechanism of Kidney-Yang toxifying herbs and preparations (Huang et al 2013). It has been one of classical methods of establishing KDS-Yang to animals. It is a widely distributed insect in China (Jepson and Heads 2016) In addition to this kind of larvae is a favorite food for tourists, and a common traditional Chinese medicine in China utilized to strengthening with tonics, toxifying the lungs, relieving cough, and treat kidney diseases(Cao CQ, 2014). We explored the effect of hellgrammite proteins on kidney yang deficiency syndrome
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