Abstract
Objective To investigate the characteristics of intestinal flora in patients with gastric cancer complicated by coronary heart disease and heart failure and the guiding value of probiotics intervention for clinical treatment. Methods (1) One hundred and sixty-eight gastric cancer patients with complications of coronary heart disease and heart failure from August 2017 to December 2020 were selected as the observation group. A total of 125 patients with coronary heart disease treated at the same time were selected as control group 1, and 89 healthy subjects were selected as control group 2. Fecal samples were retained to extract the total RNA, and high-throughput sequencing was applied to complete the analysis of microbial diversity and structure differences, so as to obtain the biological species information of the specimens. (2) Patients in the observation group were randomly divided into two equal groups of 84 patients, namely, group A and group B. Group A was treated with conventional methods, and group B was combined with probiotics intervention on the basis of group A; then, the differences in the intestinal mucosal barrier between the two groups were compared. Results The Chao, ACE, and Simpson index in the observation group were lower than those in control group 1 (P < 0.05), and the Shannon index was higher than that in control group 1 (P < 0.05). The Chao, ACE, and Shannon index in control group 1 were lower than those in control group 2 (P < 0.05), whereas the Simpson index was higher than in control group 2 (P < 0.05). The abundance of Bacteroidetes in the observation group was lower than that in control group 1 and control group 2 (P < 0.05). The abundance of Firmicutes was higher than that of control group 1 and control group 2 (P < 0.05). Four weeks after treatment, the levels of ET, D-lactic acid, and PCT in the group B were (0.10 ± 0.01), (3.99 ± 0.32), and (0.41 ± 0.10), respectively, which were lower than those in group A (0.19 ± 0.03), (4.51 ± 0.46), and (0.81 0.13). Conclusion Gastric cancer patients with complications of coronary heart disease and heart failure are associated with intestinal flora disorder, which may be involved in the occurrence and development of the disease. Probiotics intervention is helpful to repair the intestinal mucosal barrier in patients, which is worthy of popularization and application.
Highlights
Coronary heart disease is a disease caused by coronary artery stenosis or occlusion of myocardial ischemia, hypoxia, or necrosis
Gastric cancer patients with complications of coronary heart disease and heart failure are associated with intestinal flora disorder, which may be involved in the occurrence and development of the disease
Probiotics are commonly used as clinical gastrointestinal regulating drugs, regulating intestinal flora, and protecting the intestinal mucosal barrier, but there are few studies on the application of drugs in patients with gastric cancer complicated by coronary heart disease and heart failure [7]. erefore, this study focused on patients with gastric cancer complicated by coronary heart disease and heart failure to explore the characteristics of the intestinal flora of patients with coronary heart disease combined with heart failure and gastric cancer and the guiding value of probiotic intervention in clinical treatment
Summary
Coronary heart disease is a disease caused by coronary artery stenosis or occlusion of myocardial ischemia, hypoxia, or necrosis. As the course of the disease increases, it can increase the incidence of chronic heart failure [1]. The clinical treatment of coronary heart disease mainly focuses on reducing blood lipids, preventing risk factors, and symptomatic treatment. Good effects can be obtained, how to choose and take measures to reduce disease morbidity and mortality has become a hot research topic [2]. Gastric cancer is a kind of gastric cancer that originates from gastric mucosal cells, which is mainly clinically characterized by abdominal pain. It usually occurs in people aged 40–70
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
