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Abstract
Subcutaneous interstitial fluid pressure ( P i) was measured in anesthetized rats with the “wick-in-needle” technique: A thin hypodermic needle was provided with a 2- to 4-mm-long sidehole and filled with multifilamentous nylon thread. A polyethylene tube, connecting the needle to a pressure transducer, could be compressed by a screw clamp, displacing a volume of about 0.2 μl. Compression caused a marked rise in pressure, but return to control level was obtained within 1 to 5 min. Decompression caused opposite pressure changes, confirming satisfactory fluid communication between needle and tissue fluid. Control P i (measured with saline-filled needle) ranged from −2.5 to +1.0 mm Hg, with mean values of −0.65 mm Hg (SD 0.82, n = 44) on the back and −1.2 mm Hg (SD 0.8, n = 11) on the hindlimb. Similar values were obtained with the needle filled with serum or 1% hyaluronic acid. Severe reduction of femoral arterial pressure reduced hindlimb P i gradually to −3 to −4 mm Hg in the course of 1 to 2 hr. P i was also reduced after 3–7 days of dehydration (−2 to −6 mm Hg) and rose rapidly with rehydration. Edema and a rise of hindlimb P i to positive values were observed when femoral venous pressure was increased from the control level of 3 to 12 mm Hg or more for a period of 24 hr.
Published Version
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