Abstract
Addition of serum growth factors or bombesin to quiescent NIH3T3-fibroblasts leads to a simultaneous mobilization of intracellular Ca2+ and an increase in cytosolic pH which is inhibitable by dimethylamiloride. The mobilization of intracellular Ca2+ is a pH-dependent process with an optimum at pH 7.1. In quiescent cells with a pHi ≥ 6.8, inhibition of the Na+H+-antiporter by dimethylamiloride or reduction of extracellular Na+ attenuates the growth factor induced Ca2+-response. It is concluded that the growth factor induced activation of the Na+H+-antiporter facilitates the mobilization of Ca2+ by shifting the internal pH towards the optimum for the Ca2+-release.
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