INTERRELATIONSHIP BETWEEN CHANGES OF E/E′ AT REST AND AFTER EXERCISE AND NT-PRO-BNP IN MILD HYPERTENSION PATIENTS WITH STRUCTURAL CHANGES AND DYSPNOEA

Abstract

Objective: The aim was to compare the frequency of NT-pro-BNP elevation in phenotypes of mild arterial hypertension (AH) pts with left heart structural changes and heart failure (HF) symptoms based on E/E′> at rest, E/E′>13 only after exercise and E/E′<13 both at rest and exercise. Design and method: Materials and methods. We consequently enrolled 84 hemodynamic stable patients with mild AH and left ventricular myocardial index LVMI > 115 g/m2 (for male) and > 95 g/m2 (for female), left atrial volume index LAVI > 34 ml/m2, and dived them on three groups. Group A included patient with average E/e′ >13 at rest. Group B with E/e′ at rest <13 and Group C patients with E/e′ < 13 both at rest and after exercise. In all pts serum NT-pro-BNP levels (ELISA) were obtained. Results: Results. Group A included 48 pts (57,1%), Group B – 22 (26,1%) and Group C – 14 (16,6%) they didn’t differ in age (60,1 ± 1,4 vs 61,2 ± 1,7 and 62,1 ± 1,4 years), gender (29 (60,4%) vs 15 (68,18%) vs 8 (57,14%) males) and diabetes incidence (25,0% vs 19,0% vs 15,0%) and body mass index (BMI) (30,22 ± 5,24 vs 31,3 ± 5,80 vs 28,65 ± 3,59; all p>0,05). NT-pro-BNP date are demonstrated in the table.Conclusions: In mild hypertension pts with left heart structural changes and HF symptoms only E/E′ elevation at rest phenotype was associated with NT-pro-BNP elevation in 100% of cases. Heterogeneity of E/E′>13 only at exercise E/E′ both at rest and exercise phenotypes as regards of NT-pro-BNP elevation (in 68,2% and 35,7%) demonstrates the need of heart failure with preserved ejection fraction (HFprEF) criteria specification.