Interrelations Between Glycated Hemoglobin Trajectories and Left Ventricular Diastolic Dysfunction in Patients with CHD and DM-2

Abstract

IntroductionThe study of the relationship between the glycemic profile and LVDD in patients with coronary artery disease and type 2 diabetes is topical. PurposeTo analyze the relationship between LVDD and glycated hemoglobin trajectories in patients with coronary artery disease and type 2 diabetes. Material and methods130 patients with coronary artery disease and DM-2 aged 63.9±8.8 years, experience of coronary artery disease 9.69±0.49 and DM 7.3±3.89 years, in whom LVDD parameters were determined. For 2 years of observation, the trajectories were evaluated HbA1c. ResultsIn patients with preserved HbA1c <8 (n-47) and >8.1 (n-50), e`average is below 7.42 [7.38-8.20] and 7.65 [7.20-8. 54], respectively, than in which HbA1 changed (p=0.05). In groups HbA1c>8.1(n-5) and HbA1c>8.1 and became <8 (n-28) e`mean no difference. The E/e` ratio in all groups tended to increase (P=0.694). According to LVDD gradations in all HbA1 groups with a normal type, an increase in patients is recorded (groups: C from 32 to 44%; A+B from 34.04 to 40.43%; C-(A+C) from 28.57% to 32 14%, except for group C´ - reduction in patients with normal LVDD from 60 to 40%. ConclusionNegative dynamics of the e`average index was revealed in the HbA1c<8 (n-47) and HbA1c>8.1 (n-50) groups after 2 years of observation with significant differences between the points of determination, in contrast to the subgroups in which HbA1c transitions were observed. The E/e` ratio in all groups showed a tendency to increase throughout the entire observation period, which indirectly indicates the progression of diastolic dysfunction.