Intermittent social stress produces different short- and long-term effects on effort-based reward-seeking behavior

Abstract

Previous studies show that intermittent social defeat (ISD) stress increases self-administration of psychostimulants, which suggests that ISD promotes reward-seeking behavior and, ultimately, increases vulnerability to develop drug abuse. The present study investigates whether ISD alters cost/benefit evaluations to promote reward-seeking behavior and whether these alterations are time-dependent. Male rats performed two different tasks that assessed their motivation to seek and consume food rewards. An effort-discounting task in which rats chose between less and more effortful options (i.e., 1 lever-press versus 2, 5, 10 or 20 lever-presses) associated with low- and high-reward (i.e., 1 sugar pellet versus 3 sugar pellets), respectively; and a progressive ratio task in which rats had to increase their effort (more lever presses) to obtain a sugar pellet. ISD consisted of exposing animals to social defeat once every three days for ten days (4 stress episodes). Rats were tested 24–48 h after stress episodes, and 1 week and 6 weeks after the last stress episode. In the effort-discounting task, stressed animals showed a decrease in their preference for high rewards associated with more effort (i.e., 10 and 20 lever-presses). These effects were transient and not maintained one week after stress. In the progressive ratio task, stressed animals showed an increase in the number of lever presses to obtain rewards that emerged six weeks after the last stress episode. These results suggest different short- and long-term effects on the motivation for rewards after ISD and indicate temporal dynamic adaptations in the function of the brain reward system.