Abstract
(1) Background: Intermittent fasting is a nutrition practice in which individuals fast for several hours in a day, mainly with feeding time during the daylight hours. They seek to improve metabolic performance and cellular resistance to stress. In this study, we tested the fasting protocol to investigate the glycemic effect in a laparotomy perioperative period in diabetic rats and histopathologic findings. (2) Methods: The animals were diabetic-induced with alloxan. Two groups were set according to the feeding protocol: free food and intermittent fasting, whose rats could only eat 8 h in the daylight. Both groups were anesthetized, and a laparotomy was performed. We evaluated the glucose levels during the perioperative period, and we accessed organ histology seeking damage of kidney, bowel and liver after surgical trauma, and we evaluated the wound healing process. (3) Results: Glycemic levels were improved in the intermittent fasting group, especially in the post-operative period after laparotomy. Comparing both groups’ tubular damage showed interdependency with mice with worse glycemic level (Z = 2.3; p = 0.0215) and wound-healing parameters showed interdependency with rats with better glycemic status for neovascularization (Z = 2.2; p = 0.0273) and the presence of sebaceous and sweat gland in the healing process (Z = 2.30; p = 0.0215). (4) Conclusions: Intermittent fasting before surgery can be a tool to improve glycemic levels in diabetic rats, with improvement especially in the post-operative period.
Highlights
Intermittent fasting (IF) is a nutrition strategy that is showing promising results in metabolic improvement in glucose regulation, weight loss and stress resistance [1]
(3) Results: Glycemic levels were improved in the intermittent fasting group, especially in the post-operative period after laparotomy
We demonstrated that IF before surgery remarkably reduced the levels of blood glucose in diabetic rats in the perioperative period, mainly with better stabilization of the glycemic curve in the post-operative period comparing with the FF group
Summary
Intermittent fasting (IF) is a nutrition strategy that is showing promising results in metabolic improvement in glucose regulation, weight loss and stress resistance [1]. In this practice the hours of the feeding day are restricted, alternating periods from 12 to 24 h of fasting in some days of the week. This aims to promote cellular resistance, organism resilience and improve plasticity when damage occurs [2]. Results are attributed to weight loss in association with enhancement of peripheral insulin action [10,11]
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