Abstract
The present study was designed to investigate the effects of IMD/AM2 (IMD), an endogenous agonist for calcitonin-like calcitonin receptors (CLCR), on coronary and systemic hemodynamics. Ultrasonic transit time flow probes were placed around the left anterior descending artery in the anesthetized, open-chest pig. Intracoronary arterial bolus injections (IAB) of IMD, hADM13–52 and CGRP increased coronary blood flow in a dose-dependent manner. IMD at the doses studied was more potent than CGRP and hADM13–52 and did not alter systemic arterial pressure, cardiac output and cardiac index. IAB of L-NAME significantly decreased the coronary vasodilatory response (CVR) to IMD. The present data suggest that IMD possesses marked vasodilator activity in the pig coronary vascular bed. The present data further suggest the CVR to IMD in the pig is mediated by release of nitric oxide from endothelial CLCR. The degree of the CVR to IMD may serve as functional marker for the integrity of endothelial cells in resistance segments of the coronary circulation. This study was supported by Gulhane Military School of Medicine (# AR-2006-20).
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