Abstract
The most abundant excitatory neurotransmitter in the brain, L-Glu, is involved in a variety of neuronal signaling processes. This explains the keen interest in the excitatory amino acid transporter (EAAT) family and its role in the regulation of intra- and extra-cellular Glu concentrations. The human EAAT3 protein (hEAAT3) operates by an elevator mechanism to transfer the substrate from an outward-facing state (OFS) to an inward-facing state (IFS) from which the Glu can be released into the cell.
Full Text
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call