Intermediate stage atherosclerosis regression using photofrin II - mediated ultrasound sonodynamic therapy and gold nanoparticles- mediated X- rays- based Auger electron therapy

Abstract

Background and Aims : In atherosclerosis, local inflammation and associated macrophage activity can lead to foam cell- rich lesion formation, making inflammation an important target in cardiovascular diseases.In this study, we developed an experimental sonodynamic therapy system, and investigated its effectiveness on intermediate stage atherosclerosis regression accompanied by lipid based encapsulated gold nanoparticles- mediated X- rays- based Auger electron therapy, wherein diagnostic B- mode ultrasound is combined with ultrasound therapy system, with a goal of increased safety.