Abstract
BackgroundNeonatal sepsis (NS) is a life-threatening disorder and an important cause of morbidity and mortality in neonates. Previous studies showed that interleukin 8 (IL-8) may effectively and rapidly diagnose NS.ObjectiveWe conducted the systematic review and meta-analysis to investigate the diagnostic value of the IL-8 in NS.MethodsThe literature was searched in PUBMED, EMBASE, Cochrane Library, CNKI, VIP and other Chinese Medical Databases during October 1998 to January 2014 using set search criteria. Each included study was evaluated by quality assessment of diagnostic accuracy studies tool. Two investigators independently extracted the data and study characteristics, and disagreements, if any, were resolved by consensus. Meta-disc software was used to calculate the pooled sensitivity, specificity and summary diagnostic odds ratio (SDOR), I² or Cochrane Q to test heterogeneity, and meta-regression to investigate the source of heterogeneity. Funnel plots were used to test the potential presence of publication bias. False-positive report probability (FPRP) was calculated to confirm the significance of the results.ResultsEight studies (548 neonates) were included in this meta-analysis. The pooled sensitivity and specificity of IL-8 were 0.78 and 0.84, respectively, which had moderate accuracy in the diagnosis of NS. The pooled diagnostic odds ratio (DOR) and area under curve (AUC) was 21.64 and 0.8908 (Q*=0.8215), respectively. The diagnostic threshold analysis showed that there was no threshold effect. The meta-regression analysis showed the cut-off, QUADAS and onset time have no effect on the heterogeneity. The funnel plots showed the existence of publication bias.ConclusionMeta-analysis showed IL-8 had a moderate accuracy (AUC=0.8908) for the diagnosis of NS. IL-8 is a helpful biomarker for early diagnosis of NS. However, we should combine the results with clinical symptoms and signs, laboratory and microbial results.
Highlights
Neonatal sepsis (NS) is a life-threatening disorder and an important cause of morbidity (1 to 10 per 1000 live births) and mortality (15% to 50%) in neonates, especially in preterm [1, 2].NS can be defined both clinically and/or microbiologically as a systemic inflammatory response caused by infection
We conducted the systematic review and meta-analysis to investigate the diagnostic value of the interleukin 8 (IL-8) in NS
The meta-regression analysis showed the cut-off, quality assessment of diagnostic accuracy studies (QUADAS) and onset time have no effect on the heterogeneity
Summary
Neonatal sepsis (NS) is a life-threatening disorder and an important cause of morbidity (1 to 10 per 1000 live births) and mortality (15% to 50%) in neonates, especially in preterm [1, 2].NS can be defined both clinically and/or microbiologically as a systemic inflammatory response caused by infection. Neonatal sepsis (NS) is a life-threatening disorder and an important cause of morbidity (1 to 10 per 1000 live births) and mortality (15% to 50%) in neonates, especially in preterm [1, 2]. Clinical signs of NS such as fever, tachycardia, and drowsiness are nonspecific, and it is easy to misdiagnose with other common diseases such as pneumonia, respiratory distress syndrome, and intracranial hemorrhages [5]. Laboratory tests such as white blood cell count, neutrophil percentage, platelet count, and C-reactive protein (CRP) are non-specific in NS. Neonatal sepsis (NS) is a life-threatening disorder and an important cause of morbidity and mortality in neonates.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
