Abstract
Background The present study was aimed to investigate the value of blood interleukin-27 (IL-27) as a diagnostic biomarker of sepsis. Methods We searched PubMed, EMBASE, the Cochrane Library, and the reference lists of relevant articles. All studies published up to October 21, 2020, which evaluated the accuracy of IL-27 levels for the diagnosis of sepsis were included. All the selected papers were assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). We used a bivariate random effects model to estimate sensitivity, specificity, diagnostic odds ratios (DOR), and a summary receiver operating characteristic curve (SROC). Deeks' funnel plot was used to illustrate the potential presence of publication bias. Results This meta-analysis included seven articles. The pooled sensitivity, specificity, and DOR were 0.85 (95% CI, 0.72-0.93), 0.72 (95% CI, 0.42-0.90), and 15 (95% CI, 3-72), respectively. The area under the summary receiver operating characteristic curve was 0.88 (95% CI, 0.84-0.90). The pooled I2 statistic was 96.05 for the sensitivity and 96.65 for the specificity in the heterogeneity analysis. Deeks' funnel plot indicated no publication bias in this meta-analysis (P = 0.07). Conclusions The present results showed that IL-27 is a reliable diagnostic biomarker of sepsis, but it should be investigated in combination with other clinical tests and results.
Highlights
The present results showed that IL-27 is a reliable diagnostic biomarker of sepsis, but it should be investigated in combination with other clinical tests and results
Sepsis is a severe complication of severe infection, severe trauma, burns, shock, and surgery, and it can lead to septic shock and multiple organ dysfunction syndromes (MODS) [1, 2]
The results of our study clearly demonstrated that IL-27 was an accurate diagnostic biomarker for sepsis with the potential for clinical applicability
Summary
Sepsis is a severe complication of severe infection, severe trauma, burns, shock, and surgery, and it can lead to septic shock and multiple organ dysfunction syndromes (MODS) [1, 2]. The gold standard in diagnosing sepsis is microbiologic cultures, in spite of this is a delay between the clinical manifestations and the results from such cultures. Diagnostic biomarkers that can indicate a diagnosis of sepsis before the microbiological cultures are complete are needed. The present study was aimed to investigate the value of blood interleukin-27 (IL-27) as a diagnostic biomarker of sepsis. We used a bivariate random effects model to estimate sensitivity, specificity, diagnostic odds ratios (DOR), and a summary receiver operating characteristic curve (SROC). Deeks’ funnel plot indicated no publication bias in this meta-analysis (P = 0:07). The present results showed that IL-27 is a reliable diagnostic biomarker of sepsis, but it should be investigated in combination with other clinical tests and results
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