Diagnostic accuracy of miniprobe endoscopic ultrasonography in assessment of tumor invasion depth in early gastric cancer: a Meta-analysis

Abstract

Objective To evaluate the diagnostic accuracy of miniprobe endoscopic ultrasonography(EUS)in assessment of tumor invasion depth in early gastric cancer. Methods We searched on the PubMed, Cochrane Library, Embase, CNKI, WanFang data, VIP data for relevant studies published.Stata 14.2 software was used to perform the Meta-analysis for sensitivity, specificity, positive likelihood ratio(LR), and negative LR, diagnostic odds ratio and 95% CI.A summary receiver-operating characteristic(SROC)curve was constructed, the area under the curve(AUC)was calculated, and the diagnostic value was evaluated.Furthermore, to explore the potential sources of heterogeneity, we used meta-regression to estimate the effect of the characteristics of the studies on the diagnostic accuracy of miniprobe EUS, and a subgroup analysis was performed.We assessed the publication bias using Deeks′Funnel plot. Results Sixteen studies with a total of 3 168 tumors were included in the analysis.The pooled sensitivity, specificity, positive likelihood ratio(LR), negative LR, diagnostic odds ratio and 95% CI and area under curve(AUC)were 0.85(95% CI: 0.78-0.90), 0.73(95% CI: 0.65-0.80), 3.2(95% CI: 2.4-4.1), 0.20(95% CI: 0.14-0.30), 16(95% CI: 9-26). The AUC of SROC curve was 0.85.No significant publication bias was found with Deeks′Funnel plot. Conclusion Miniprobe EUS can not accurately diagnose or exclude the M/SM1 layer invasion in early gastric cancer, but it still can greatly improve the diagnostic accuracy of invasion depth in early gastric cancer. Key words: Miniprobe endoscopic ultrasonography; Early gastric cancer; Invasion depth; Meta-analysis