Interleukin-10 (IL-10) gene polymorphisms and prostate cancer susceptibility: Evidence from a meta-analysis

Abstract

Prostate cancer is the second most frequent cancer in men. The frequency of the prostate cancer is greatly varies in different populations of the world. Three common polymorphisms in promoter region of interleukin-10 (IL-10) gene viz. -1082A > G, -819C > T and -592C > A are extensively studied in prostate cancer with inconclusive results. So, a meta-analysis was performed to assess the association between these three IL-10 gene polymorphisms and risk of prostate cancer susceptibility. Suitable studies were retrieved by electronic databases search and odds ratios (ORs) with 95% confidence intervals (CIs) were used as association measure. All the statistical analyses were conducted in the Open Meta-Analyst program. In our meta-analysis we included 17 studies (10,718 samples), 12 studies (8810 samples) and 13 studies (7801 samples) for -1082A > G, -819C > T and -592C > A polymorphisms respectively. The result of the -592C > A polymorphism revealed low heterogeneity with no association in the overall analysis (ORAvs.C = 1.05, 95% CI = 0.99–1.12, p = 0.09, I2 = 35.89%). In ethnicity based stratified analyses, significant association was found in Caucasian population with prostate cancer using allele contrast model (ORAvs.C = 1.10, 95% CI = 1.02–1.18, p = 0.01, I2 = 19.37%), homozygote model (ORAAvs.CC = 1.32, 95% CI = 1.05–1.67, p = 0.01, I2 = 0%), and dominant model (ORAA+CAvs.CC = 1.11, 95% CI = 1.00–1.24, p = 0.04, I2 = 40.75%). No such results were found in the Asian population. In the other two polymorphisms i.e. -1082A > G and -819C > T, no significant association with prostate cancer was observed. In conclusion, results of present meta-analysis suggested that IL-10-592C > A polymorphism plays a role in the etiology of the prostate cancer in the Caucasian population.