Abstract
AIMS: To determine the effect of Mat Pilates on serum levels of interleukin-10 and brain-derived neurotrophic factor in women with multiple sclerosis.METHODS: Thirty women with multiple sclerosis with mild to moderate disability were recruited and randomly divided into equal Pilates training and Control groups. Patients in the training group accomplished a Pilates program three times a week for eight weeks. The Control group maintained their routine lifestyle. The serum level of interleukin-10 and brain-derived neurotrophic factor were measured before and after the protocol. The differences between groups were assessed by using analysis of covariance test to compare post-tests by considering covariate pre-tests (assuming a p-value <0.05 as significant).RESULTS: There were no significant changes in interleukin-10 (13.09±5.36 ng/ml in the Pilates training group compared to 13.21±4.76 ng/ml in the Control group, p= 0.81), whereas an increase in brain-derived neurotrophic factor was observed after eight-week Pilates training (11550.14±2619.60 ng/ml in the Pilates training group compared to 9664.35±3161.66 ng/ml in the Control group, p= 0.03).CONCLUSIONS: The results suggest that the intensity and duration of this protocol was not related to significant changes in interleukin-10, but was followed by an increase in brain-derived neurotrophic factor in these patients. Based on this finding, physical activity according to the individual’s ability is recommended for patients with multiple sclerosis, in parallel with drug therapy.
Highlights
Cytokines have a crucial role in the pathogenesis of multiple sclerosis (MS) an inflammatory disease so that pro-inflammatory cytokines exacerbate MS, and anti-inflammatory cytokines improve it [1]
There were no significant changes in interleukin-10 (13.09 ± 5.36 ng/ml in the Pilates training group compared to 13.21 ± 4.76 ng/ml in the Control group, p = 0.81), whereas an increase in brain-derived neurotrophic factor was observed after eight-week Pilates training (11550.14 ± 2619.60 ng/ml in the Pilates training group compared to 9664.35 ± 3161.66 ng/ml in the Control group, p = 0.03)
We found no difference in the serum concentration of IL-10 after eighth-week Mat Pilates program
Summary
Cytokines have a crucial role in the pathogenesis of multiple sclerosis (MS) an inflammatory disease so that pro-inflammatory cytokines exacerbate MS, and anti-inflammatory cytokines improve it [1]. IL-10 therapy is an effective treatment method for neuro-immune diseases [1]. IL-10 has an important role in immune and inflammatory responses which are regulated by growth and /or differentiation of B cell, T helper cell, and T regulatory cell [3]. IL-6, as a myokine released by contracting the skeletal muscle, causing an increase in IL-10 [5, 6]. Contraction of skeletal muscle is another major source of IL-10 and leads to its increase during moderate exercise [7]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
