Abstract
The inflamed joints in rheumatoid arthritis patients are ideally suited for gene therapy applications to acquire local production of potent anti-inflammatory biologics. The need for precise and absolute targeting as for treating cancer is not necessary in rheumatoid arthritis. However, the challenge is to obtain long-term transgene expression. For this purpose we used in this study HIV-based lentiviruses (LV) for the stable transduction of the murine synovium.
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