Abstract
The effect of interleukin 1 (IL-1) was studied on leukemic cells from 12 patients with B cell chronic lymphoid leukemias including two cases of hairy cell leukemia (HCL), two cases of HCL-variant (HCL-V), one case of prolymphocytic leukemia (PLL), and seven cases of chronic lymphocytic leukemia (CLL). In most cases, IL-1 induced differentiation characterized by increments of sIgγ +, sIgμ + and PCA-1 + cells, and a decrement of CD5 + cells, and activation characterized by increments of CD23 + and HC2 + cells, but induced the proliferation of leukemic cells only in two HCL-V cases. Among these effects, increment of sIg + cells was observed more frequently in non-CLL ( 4 5 cases) than in CLL ( 2 7 cases), and increments of sIgγ +, CD23 + and PCA-1 + cells were induced more frequently by IL-1β than by IL-1α. These results suggest that IL-1, especially IL-1β, plays a significant role in the differentiation and activation of leukemic cells, but has only a minor role as an extrinsic/autocrine growth factor. IL-1 may be useful for studying the differentiation pathway of leukemic cells in B cell chronic lymphoid leukemias, particularly those with more mature cells such as PLL and HCL.
Published Version
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