Abstract
Interferon-γ Autoantibodies as Predisposing Factor for Nontuberculous Mycobacterial Infection
Highlights
To the Editor: Recent advances in the understanding of antimycobacterial immune response have led to descriptions of predisposing conditions to dissemination of nontuberculous mycobacteria (NTM) infection
The patient reported intense dorsal spine pain. She was diagnosed with multifocal vertebral osteomyelitis, and tissue specimens tested positive for M. intracellulare
Treatment was changed to azithromycin, rifabutin, ethambutol, and amikacin for 2 weeks, rifabutin and moxifloxacin, which led to clinical improvement
Summary
To the Editor: Recent advances in the understanding of antimycobacterial immune response have led to descriptions of predisposing conditions to dissemination of nontuberculous mycobacteria (NTM) infection. The patient reported intense dorsal spine pain. The recurrent NTM infection led us to investigate her immune status. The detection of IFN-γ autoantibodies in high levels explained these abnormalities.
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