Interference of diabetes on volatile anesthetic-induced myocardial protection

Abstract

Volatile anesthetic pre-or post-conditioning presents protective effects against iscbemic damage of myocardium,by activating endogeneous protection mechanisms.Recent studies show that hyperglycemia may block anesthetic conditioning-induced protective effect,and that volatile anesthetics inhibit insulin release,producing hyperglycemia.Volatile anesthetic-produced myocardial protective effects may have a promising future in clinical application,and more attention should be paid on the relationship between diabetes and myocardial protection of volatile anesthetic. Key words: Volatile anesthetic; Sevoflurane; Myocardial protection; Diabetes