Abstract
ABSTRACT The study of the reactions of the embryonic organism to chemical substances is one of the main approaches to the analysis of embryonic development. Well known is the use of the lithium ion which produces in embryos of diverse species a variety of developmental abnormalities. However, in the case of a substance like lithium an analysis of the particular sequence of chemical reactions which leads eventually to the manifestation of a morphological abnormality encounters a peculiar difficulty. Since lithium reacts with numerous proteins, a wide range of reactions has to be considered as the initial step in the teratogenic mechanism.
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