Abstract
Barnacles, a tenacious, cosmopolitan biofouling organism, produce a micron-thick layer of proteinaceous amyloid-like underwater adhesive. Derived from consensus barnacle cement sequences from Amphibalanus amphitrite, we have identified a charge pattern domain which plays a key role in nanomaterial formation. Synthetic barnacle cement peptides (BCPs) and their randomized variants were generated to interrogate charge patterns in amyloid formation. To better understand the role of structure and sequence in BCP behavior at interfaces, we perform depletion assays with silica nanoparticles where relative adsorption between labelled sequences are quantified by measuring fluorescence from the depleted solution.
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