Interest in daily clinical practice of screening for gouty disease in patients with psoriatic arthritis

Abstract

Abstract Objectives Psoriatic arthritis (PsA) and gout are two prevalent rheumatic diseases, that can be associated as part of a rheumatism known as “Psout”. Both conditions are associated with cardiovascular (CV) risk, thus their co-occurrence could have significant implications for the management of CV risks and patient care. This study aimed to determine the prevalence of gout within a PsA patient cohort and, consequently, to identify factors associated with this pathological association. Methods This is an observational, descriptive, cross-sectional, single-center study, including patients diagnosed with PsA. Demographic, clinical, biological and imaging data were collected. We identified the proportion of patients simultaneously affected by PsA and gout and compared characteristics between those with and without gout. Results The prevalence of gout among PSA patients was 9.8% (12/122), with a prevalence of 23% for asymptomatic hyperuricemia and 7.4% presenting with specific ultrasound signs of gout. Significant associated factors in univariate analysis included weight, hypertension, diabetes, certain medications (diuretics, aspirin, lipid-lowering agents), impaired renal function, elevated fasting blood glucose, lipid abnormalities, and specific US signs of gout. Conclusion Our study has described the existence of patients simultaneously affected by PsA and gout (“Psout”). Performing joint ultrasound along with uric acid level measurements in PsA patients can enable personalized therapeutic care.