Interdisciplinary integration of microbiology and psychiatry in diagnostics of progressive paralysis

Abstract

Annotation. The article argues the importance of interdisciplinary integration of theoretical and clinical disciplines in the preparation of a doctor. The purpose of the work is to ensure the formation of an integrated system of knowledge, skills and practical skills necessary to justify the diagnosis of neurosyphilis of syphilis, methods of laboratory diagnostics and etiological therapy of progressive paralysis, which are laid down when studying a course of Microbiology and are fixed when mastering the educational discipline of Psychiatry and Narcology. Over the past 30 years, an increase in the incidence of syphilis has been observed throughout the world, and the number of cases of neurosyphilis and late forms of the disease has been increasing. This can be attributed to the late visits of patients to the doctor, the widespread uncontrolled unqualified treatment and the frequent association of syphilis and HIV infection. The main clinical signs of progressive paralysis are cognitive impairment, impaired regulation of voluntary activity, emotional and behavioral disorders, pseudo-neurotic symptoms, uncriticality, pathognomonic and nonspecific neurological disorders. For diagnosis, neuropsychological scales are used as screening techniques. As a rule, the diagnosis is confirmed by positive standard serological reactions: the Wassermann complement binding reaction, the pale treponema immobilization reaction, and the immune fluorescence reaction. For the diagnosis of late and latent forms of syphilis, the result of which is the development of progressive paralysis, Wassermann reaction with cerebrospinal fluid is also used. From modern studies, enzyme immunoassay and the molecular genetic method, the Lange reaction are used. Of great importance are laboratory indicators of the presence of inflammatory phenomena and neuroimaging methods. Thus, reliable diagnosis of progressive paralysis using the clinical anamnestic method, neuropsychological scales, laboratory methods of research and assessment of neurological status will help to solve the main task of the doctor — to help the patient by prescribing reasonable etiotropic and pathogenetic therapy.