Interdependence Between Body Weight, Depth of Inflammation and Functional Capacity of the Pancreas in Patients with Primary Osteoarthritis and Type 2 Diabetes

Abstract

Osteoarthritis (OA) is the most common joint disease and the leading cause of disability. OA not only affects the quality of life and shortens the functionally active period, but also increases mortality due to the progression of comorbidities, such as obesity, insulin resistance, type 2 diabetes (T2DM), cardiovascular disease. The objective: to identify pathogenetic links between OA and T2DM in order to improve the approach to diagnostic and treatment. Materials and methods.Patients with primary OA and T2DM without exacerbation were divided into three groups according to body mass index (BMI): Group I – 33 patients, Group II – 35 patients, Group III – 34 patients. The mean age of the patients was 61.57±7.97 years (from 29 to 68 years). All patients with comorbidity of T2DM and OA were comparable according to clinical, gender criteria, severity of comorbid pathologies and received treatment. The control group included 30 healthy people. Results. A statistically significant increase in the level of ESR was found in all studied groups compared to the control group (р<0.05). During the analysis of the CRP level in the studied groups, a statistically significant increase in the level of this indicator was found with increasing BMI (р<0.05). A statistically significant progression of T2DM with increasing BMI was recorded for all indicators (р<0.05). A statistically significant increase in total WOMAC index and VAS index with increasing BMI (р<0.05) was established, which indicates the progression of primary OA in comorbidity with T2DM with increasing BMI. The obtained data demonstrated the clinical significance of body weight increase, the accumulation of adipose tissue, and the deepening of the functional insufficiency of the pancreas for the progression of joint and pain syndromes in OA on the background of T2DM. Conclusions. The results of the study showed a statistically significant increase in the manifestations of low-intensity inflammation and the progression of incretory and excretory insufficiency of the pancreas with an increase in the body mass index in patients with primary osteoarthritis (OA) and type 2 diabetes mellitus (T2DM). The interdependence of the inflammatory syndrome with the accumulation of adipose tissue and the deepening of obesity in patients with comorbidity of OA and T2DM has been proven. It is necessary to continue further studies of osteoarthritic changes in the joints in T2DM patients, to develop diagnostic schemes and drug therapy for the combined course of these diseases.