Abstract
ABSTRACT Following intravenous injection of tracer doses of 4-14C-cortisol and 1,2-3H-cortisone, urinary metabolites of cortisone and cortisol were extracted and purified in 3 normal adult subjects, 1 child and 2 adult men treated with ACTH. Study of the 3H/14C ratio in the different metabolites and their specific activity as related to 14C and to 3H showed that there is extensive but not complete interconversion between cortisol and cortisone. Although the data obtained are those expected if cortisol alone was secreted by the adrenal cortex of the subjects studied, the lack of sensitivity of the theoretical model employed did not permit us to exclude cortisone secretion.
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