Abstract
Aim: We aimed to investigate biomarkers of inflammation, oxidative stress as surrogate markers of subclinical atherosclerosis in patients with Type 2 diabetes mellitus (T2DM). Materials& methods: Subjects were grouped based on carotid intima media thickness (CIMT). Group 1: healthy controls (CIMT <0.57mm); Group 2: T2DM without subclinical atherosclerosis (CIMT <0.57mm); Group 3: T2DM with subclinical atherosclerosis (CIMT ≥0.57mm). Results: Significantly higher MDA, Hs-CRP, Ox-LDL, PTX-3, IL-6, ICAM-1 and lower FRAP, IL-10 levels in T2DM groups compared with controls (p = 0.001). Changes were more significant in Group 3 compared with Group 2. ICAM-1 had the highest sensitivity and specificity at a cut-off value of >40.34ng/mlcompared with Ox-LDL and PTX-3 (p<0.001). Conclusion: ICAM can be considered as an alternate surrogate biomarker of CIMT.
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