Abstract
Octacalcium phosphate (OCP) is a layered calcium phosphate compound that has attracted significant attention as a new biomaterial due to its excellent biocompatibility. Its interlayer structure, known as HPO4-OH layer, can be easily replaced by dicarboxylic acid. However, the kinetical ionic and/or molecular exchange process of substituted dicarboxylic acid into OCP interlayer is still unclear. Therefore, in this study, we evaluate the molecular exchange process for thiomalate (SH-malate)-substituted OCP (OCP-SH-malate) during the phase conversion process to other phases in disodium hydrogen phosphate solution (Na2HPO4). When the OCP-SH-malate is immersed in 1 mol/L Na2HPO4 at 40 °C while shaking at 200 rpm, SH-malate, first desorbed from the interlayer of OCP-SH-malate and the HPO4-OH layer structure, is formed at the interlayer where the SH-malate was dissolved. The HPO4-OH layer structure is unstable, making it easily convert to hydroxyapatite (HAp) via dehydration upon further immersion. During this reaction, besides the dissolution of marginal edges of the crystals, crystals morphology was no obvious changes, neither were there evidences of dissolution and collapsing of OCP crystals nor nucleation of newly created crystals.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
