Abstract
Molecularly Imprinted Polymers (MIP) are synthetic materials used as a tool to enhance the selectivity in different analytical approaches, such as solid-phase extraction, chromatography, and sensing devices. Knowing the mechanism involved in the interaction between the template and monomer is essential for a further successful application. However, studies on this topic are scarce. This work evaluates the involved mechanisms in the template-monomer interaction for a lumefantrine MIP system, an antimalarial drug. Field-emission gun scanning electron microscopy, thermal analysis, X-ray diffraction, and density functional theory were applied to determine the mechanism involved in two MIPs obtained in different conditions. A new parameter, named Molecularly Imprinting Factor (MIF), was proposed to evaluate the contribution of specific interactions in the sorption of the analyte by the MIP structure. MIF allows direct insights into specific binding, non-specific contributions, interaction nature, behavior predictability, system acid-base behavior, pre-screening pairs capability, and binding site affinities evaluation. Two interaction types were observed, covalent and non-covalent, when methacrylic acid and 2-vinyl pyridine were used as monomers, respectively. Therefore, the use of methacrylic acid formed a sorbent inappropriate for solid-phase extraction since the binding is not reversible. On the other hand, 2-vinyl pyridine-lumefantrine binding was reversible, and MIF = 0.59 (59.02% of specific site sorption) indicates that the predominant mechanism in the sorption is specific.
Highlights
Imprinted Polymers (MIPs) are synthetic materials used to enhance selectivity in different analytical approaches, such as solid-phase extraction, chromatography, and sensing devices [1,2,3,4]
Molecularly Imprinted Polymers (MIP) are synthesized by polymerizing functional monomers and crosslinkers around a template, which can be the analyte of interest itself or a structural analog molecule, leading to the cross-linked formation of threedimensional selective cavities of equivalent size shape, and chemical affinity
The present study evaluates the type of interaction between template and monomer in a MIP for lumefantrine, an antimalarial drug
Summary
Imprinted Polymers (MIPs) are synthetic materials used to enhance selectivity in different analytical approaches, such as solid-phase extraction, chromatography, and sensing devices [1,2,3,4]. This work evaluates the involved mechanisms in the template-monomer interaction for a lumefantrine MIP system, an antimalarial drug. Field-emission gun scanning electron microscopy, thermal analysis, X-ray diffraction, and density functional theory were applied to determine the mechanism involved in two MIPs obtained in different conditions.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call