Abstract
The interactions of taurine with GABA B receptors were studied in membranes from the brain of the mouse by measuring the binding of [ 3H]baclofen and that of [ 3H]GABA in the presence of isoguvacine. Taurine displaced ligand binding to GABA B receptors concentration-dependently with an IC 50 in the micromolar range. The effects of baclofen on the release of taurine and GABA from slices of cerebral cortex of the mouse were assessed using a superfusion system. Potassium-stimulated release of both [ 3H]taurine and [ 3H]GABA was unaffected by baclofen but potentiated by δ-aminovalerate. The enhancement of release of [ 3H]taurine by δ-aminovalerate was partially antagonized by baclofen, suggesting that baclofen-sensitive receptors could modify the release.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
