Interactions of dichloro-bis(η 5-cyclopentadienyl)titanium(IV) with nucleosides

Abstract

The interactions of dichloro-bis(η 5-cyclopentadienyl)titanium(IV) (titanocene dichloride, Cp 2TiCl 2) with nucleosides have been studied in methanolic solutions. Complexes of the general formula [Cp 2Ti(Nucl)MeOH]Cl 2 were isolated. The nucleoside complexes with one N(1)H ionizable imino proton (i.e. inosine and guanosine) undergo ionization in alkaline solution and complexes of the formula [Cp 2Ti(NuclH +)] Cl were isolated. All complexes have been characterized by elemental analyses and various spectroscopic techniques. In the first series of complexes, [Cp 2Ti(Nucl)MeOH]Cl 2, the nucleosides act as monodentate ligands with an intramolecular hydrogen bond between the coordinated methanol and the C6O group, while in the second, [Cp 2Ti(NuclH +)] Cl, they coordinate through both their N7 and O6 atoms.