Interactions of cholinergic agonists with pulmonary neuroepithelial bodies using an in situ mouse lung slice model

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Pulmonary neuroepithelial bodies (NEBs), occurring as densely innervated groups of neuroendocrine cells in the airway epithelium, were recently suggested to represent complex sensory airway receptors. Despite the considerable amount of morphological and neurochemical data, none of the functional hypotheses have so far been fully established because reliable in vitro models are not available. Recently, our research group has developed an in situ lung model for the functional study of NEBs in a fluorescent live cell imaging set-up.