Abstract
1. X-rays in combination with urethane or mustard gas exhibit an additive effect as regards the formation of sex-linked recessive lethal mutations and chromosome breaks when applied toDrosophila melanogaster spermatozoa. 2. Their action in combination on the formation of translocations is synergistic. 3. The ends of chromosomes broken by X-rays, mustard gas, and urethane are as capable of rejoining with those produced by the same agent as the X-ray produced-ones are of rejoining with those produced by either mustard gas or urethane to form chromosomal disarrangements.
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