Abstract
IN previous publications dealing with ion transport across in vitro segments of rabbit terminal ileum, we have demonstrated that sodium is actively transported from mucosa to serosa and that the presence of an actively transported sugar in the mucosal solution increases the rate of active sodium transport by means of an interaction with the sugar transport per se1–3. In addition, we have presented a model for the sodium–sugar interaction3 which is consistent with the demonstration of Bihler et al. that the entrance of actively transported sugars into the intestinal cell is dependent on sodium4. These findings, together with Csaky's observations that sodium is necessaiy for the active intestinal transport of amino-acids and pyrimidines, as well as active sugar transport5, led us to investigate the effect of actively transported amino-acids on sodium transport by rabbit ileum.
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