Abstract
In adult male Wistar rats (Rattus norvegicus albinus) gingival irritation provided by means of wire silk ligatures around the cervix of first left lower molars, for a duration of 77 days, caused gingival inflammatory changes. In the rats receiving also daily one i.p. injection of sodium 5,5‐diphenythydantoinate (phenytoin), during 70 days, there was no macroscopical change of the gingiva of non‐ligated first right lower molars. However, in the first left lower molars, the association of silk ligature‐plus‐phenytoin administration elicited gingival overgrowth. The rat was seen as a satisfactory animal model for studies of phenytoin‐induced gingival changes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
