Abstract
There have been numerous studies of the interactions of certain phenols with nonionic macromolecules—particularly those dealing with a loss of antimicrobial properties of the phenols when combined with nonionic polymers. Relatively little attention, however, has been given to the possible disruption of the solubilizing and stabilizing properties of the polymers themselves when in combination with certain phenols. Miscibility titration studies were made by interacting the following polymers: PEG, PPG, PVP, and methylcellulose with the following phenols: catechol, pyrogallol, resorcinol, hydroquinone, tannic acid, and phenol. Photometric turbidimetric titration studies of interacting polyoxyethylene ethers, polyoxyethylene monostearates, and polysorbates with tannic acid were also carried out. Dextrose altered the complexing tendency of tannic acid by decreasing the solubility of tannic acid in PEG 6000 and increasing its solubility in PVP. Since tannic acid was found to interact strongly with nonionic hydrophilic polymers, its possible influence upon the stability of various pharmaceutical formulations containing nonionic hydrophilic polymers should not be overlooked.
Published Version
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