Abstract
The interaction of methylene blue (MB) with poly(dA)-poly(dT) has been studied. It was revealed that MB binds to this polynucleotide by strong and weak modes. It was shown that the strong binding mode of MB is realized by semi-intercalation. Apart from the strong mode, this ligand binds to AT-sequences by weak electrostatic modes as well. Values of the binding constant [Formula: see text] and number of base pairs [Formula: see text] per binding site of MB for the mentioned modes were determined. It was shown that at the interaction with AT sequences MB does not behave itself as a groove binding compound.
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