Abstract
Budding is the final step of the late phase of retroviral life cycle. It begins with the interaction of Gag precursor with plasma membrane (PM) through its N-terminal domain, the matrix protein (MA). However, single genera of Retroviridae family differ in the way how they interact with PM. While in case of Lentiviruses (e.g., human immunodeficiency virus) the structural polyprotein precursor Gag interacts with cellular membrane prior to the assembly, Betaretroviruses [Mason-Pfizer monkey virus (M-PMV)] first assemble their virus-like particles (VLPs) in the pericentriolar region of the infected cell and therefore, already assembled particles interact with the membrane. Although both these types of retroviruses use similar mechanism of the interaction of Gag with the membrane, the difference in the site of assembly leads to some differences in the mechanism of the interaction. Here we describe the interaction of M-PMV MA with PM with emphasis on the structural aspects of the interaction with single phospholipids.
Highlights
In the late phase of retroviral life cycle, all structural proteins are produced in a host cell as a polyprotein precursor Gag
While in case of Lentiviruses the structural polyprotein precursor Gag interacts with cellular membrane prior to the assembly, Betaretroviruses [Mason-Pfizer monkey virus (M-PMV)] first assemble their virus-like particles (VLPs) in the pericentriolar region of the infected cell and already assembled particles interact with the membrane
Gag proteins of most retroviruses are immediately after the synthesis transported to the plasma surface where they interact with the plasma membrane (PM) and assemble to an immature viral particle simultaneously with its budding
Summary
In the late phase of retroviral life cycle, all structural proteins are produced in a host cell as a polyprotein precursor Gag. Gag proteins of most retroviruses (formerly described as C-type retroviruses) are immediately after the synthesis transported to the plasma surface where they interact with the plasma membrane (PM) and assemble to an immature viral particle simultaneously with its budding.
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