Abstract
Due to our previous findings about the role of GABAegic neurotransmission in anxiolytic effects of Citrus aurantium L. essential oil, we are now presenting flomazenil interaction with this herb, as an antagonist of benzodiazepines at GABA receptor. The study was performed on 84 male albino mice assigned to 14 groups of six. The animals were injected intraperitoneally with the Citrus aurantium L. essential oil for 5 days. On the fifth day, either normal saline or flomazenil (0.1 mg/kg) was injected to the experimental groups. Thirty minutes after the injection, all the groups were assessed for anxiety-related behavior by elevated plus-maze test. In groups receiving Citrus aurantium L. essential oil at doses of 2.5 and 5 percent, the time spent in the open arms increased significantly (P aurantium L. essential oil regarding the increment in the number of entries to the open arms and the time spent in the open arms (P aurantium L. essential oil induces its anxiolytic effects like benzodiazepines, in the same site at GABA receptor.
Highlights
Anxiety is common psychopathies that involve many persons [1]
The findings show that, oxygen monoterpenes, which are among aromatic hydrocarbons, are more frequent in northern Citrus aurantium L
Southern Citrus aurantium L. is richer in basic components of essential oil, so it has a better quality in terms of aroma [7]
Summary
Anxiety is common psychopathies that involve many persons [1]. Various neurotransmitter systems such as GABAergic, noradrenergic and serotonergic systems are responsible for anxiety symptoms [2]. GABA is the most important neurotransmitter in the brain affecting such behaviors as learning, pain, memory, paroxysm, and anxiety [3]. As the brain develops, the ability to cope with the stressors and responding to them develops. Excessive excitation or weak inhibition will lead to restlessness, anxiety, high blood pressure and insomnia. There are oxides in northern Citrus aurantium L. essential oil, and not in the southern one. The findings show that, oxygen monoterpenes, which are among aromatic hydrocarbons, are more frequent in northern Citrus aurantium L This sesquiterpene, which has anti-bacterial effects of terpenic hydrocarbons which are responsible for the aroma and healing effects of the essential oil, has a higher percentage in the southern essential oil. Southern Citrus aurantium L. is richer in basic components of essential oil, so it has a better quality in terms of aroma [7]
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