Abstract
Anxiety is among the most common disorders affecting a great number of people. Different neurotransmitter systems, such as GABAergic system, play an important role in emergence of anxiety-related behaviors. In this study, we have investigated the effect of Citrus aurantium L. essential oil on anxiety and its interaction with GABAergic pathways. Male mice were assigned into control, sham, and experimental groups. Intraperitoneal injection of Citrus aurantium L. essential oil was applied at doses of 0.5, 2.5, and 5 percent for 5 days. Diazepam (0.1 mg/kg) was injected on the fifth day, thirty minutes before applying Citrus aurantium L. essential oil. The anxiety-related behavior of mice was then assessed using elevated plus-maze test. In groups receiving Citrus aurantium L. essential oil at doses of 2.5 and 5 percent, the percent time spent in the open arms increased significantly (P Citrus aurantium L. essential oil resulted in increasing in the number of entries to the open arms and the percent time spent in the open arms (P Citrus aurantium L. essential oil can reduce anxiety-related behaviors in male mice thah may act via GABAergic system.
Highlights
Anxiety is among the most serious and most common disorders in life which, compare to depressive disorders, How to cite this paper: Khosravi, M., Khakpour, S., Adibi, L. and Jahromy, M.H. (2014) A Study of the Effect of Citrus aurantium L
In terms of the percent time spent in the open arms, there was a significant difference between the groups that were injected with doses of 2.5 and 5 percent and the control groups (P < 0.001)
Injection of diazepam and citrusaurantium L. essential oil together increases the percent time spent in the open arms significantly (P < 0.01)
Summary
Anxiety is among the most serious and most common disorders in life which, compare to depressive disorders, How to cite this paper: Khosravi, M., Khakpour, S., Adibi, L. and Jahromy, M.H. (2014) A Study of the Effect of Citrus aurantium L. On an elementary level, is nothing but a series of biochemical actions or changes in body and brain, such as the increase of adrenaline (which causes rapid heartbeat) or the reduction of dopamine (which helps soothing headache). These biochemical changes call for more attention for the source of anxiety. It is often accompanied by panic, fear, pain in the chest or stomach, shortage of breath, rapid heartbeat, or dizziness. It can emerge in the form of uneasy and recurring thoughts or compulsory and uncontrollable behaviors [2]
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