Abstract
It is well known that certain drugs are markedly accumulated in the melanin-containing tissues of the eye. It results from the affinity of melanin to these drugs and may be primary cause of retinal impairment. The interaction of drugs commonly used to treat ocular diseases with ocular melanin in vitro was investigated. The results indicate that procaine penicillin, oxytetracycline, pantocaine and procaine have the high affinity to melanin, similar to chloroquine. The affinity of chloramphenicol, sulphacetamide and atropine is lower. Cloxacillin and fluorescein do not bind to melanin. The nature of binding as well as the kinetics of the drug-melanin interaction is discussed.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call