Abstract
By using diffuse reflectance spectroscopy, the ethanolmediated interaction between dextroamphetamine sulfate and spray-dried lactose in solid-solid mixtures was studied. Discoloration of the powder mixtures was accelerated by the presence of the amine and by storage at elevated temperatures. Two new absorption maxima were observed in the reflectance spectra of heated samples. One at 340 nm. was attributed to the chemisorption of the amine molecules on the surface of the sugar, while a second appeared at 295 nm. and was attributed to the interaction between amine molecules and the sugar. The brown material from the discolored samples was identified as dextroamphetamine-hydroxymethylfurfural, and the mechanism of the browning reaction was postulated. The rate of browning was determined by plotting remission function versus time at 295 nm. for mixtures of dextroamphetamine sulfate and spray-dried lactose at three temperatures. Arrhenius-type plots were also obtained and were used to approximate the browning rate at 25°.
Published Version
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