Abstract
Two basic polyelectrolytes which function as antiheparin agents, protamine sulfate and Polybrene, were evaluated as to their effect on human blood. It was found that both drugs were potent agglutinins at concentrations as low as 0.01 mg/ml. The studies presented suggest that the erythrocyte functioning as a polyanion and serum components with negative groups interact with the basic polyelectrolytes. The drugs differ; Polybrene appears to have a greater affinity for the red cell while protamine sulfate appears more avid for serum components. Both agents induce severe erythrocyte alterations resulting in liver and splenic sequestration and a shortening of the red cell survival time.
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