Abstract
Polycarbazole-titanium dioxide (PCz/TiO2-8) nanocomposite was synthesized for the first time by in-situ oxidative polymerization with ammonium per sulphate as an oxidizing agent in the presence of TiO2 nanoparticles and characterized by SEM, TEM, FTIR, DTA and TGA techniques. The results of above analysis confirmed that the incorporation of TiO2 nanoparticles in PCz indicating the formation of the nanocomposite due to strong interaction between TiO2 and PCz matrix responsible for enhancing the properties as compared to pristine PCz. The PCz/TiO2-8 nanocomposite was tested for antimicrobial activity and was found to exhibit the activity against gram negative as well as gram positive strains at micromolar concentrations. SEM and TEM results show that PCz has polymerized on the surface of the TiO2. The four types of 3D molecular field descriptors or field points as extrema of electrostatic, steric, and hydrophobic fields are explained. These field points are used to define the properties necessary for a molecule to bind in a characteristic way into a specified active site. A molecular docking simulation was used to predict the modes of interactions of the drugs (PCz and PCz/TiO2-8) with DNA. The molecular docking conclusion indicated that the modes of interactions between the two (PCz and PCz/TiO2-8) and DNA helix can be regarded as groove binding.Keywords: Titanium dioxide, SEM, nanocomposite, antimicrobial study.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call