Abstract
Co-effects of microelectrophoretic application of 2-amino-5-phosphonovalerate (APV), ketamine, 6,7-dinitroqinoxaline-2,3-dione (DNQX), kynurenate (Kyn) and spantide on 34 spinal dorsal horn neurons were studied. Co-application of spantide and APV or DNQX produced a synergetic inhibition of responses by tibial stimulation in 10 23 and 3 8 neurons, respectively, and also in 3 8 neurons by administration of dl-sodium homocysteate. Spantide enhanced APV- or ketamine-induced inhibition of C responses of 8 19 neurons to sural stimulation, DNQX induced that of 2 4 neurons to gastrocnemius-soleous stimulation (GS), and Kyn induced that to both sural ( 8 19 ) and GS ( 2 4 ). The results suggest an interaction of SP and NMDA, non-NMDA receptors in processing spinal nociception.
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