Interaction between homocysteine, antioxidants and lipids in patients with carotid atherosclerosis

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Background and Aims : The purpose of this study were find relationship between homocysteine, total antioxidant status(TAS ), superoxide dismutase(SOD), glutation peroxidase(GPX) and lipids in patients with carotid atherosclerosis.Methods: 89 patients with ACA (age 59.4±1.7 years) were divided into 2 groups. Group I comprised 51 patients, with hemodynamically insignificant stenosis of CA (<50%) and IMT 0.95±0.04mm. Group II 38 patients with hemodynamically significant stenosis (>50%), IMT was 1.1±0.1mm. Control group 49 healthy patients.Results: In group I Correlation was positive(from r=0.500 to r=0.628). Homocysteine increased up to 17.0±0.3 mkmol/l. TAS up to 2.20±0.03mmol/l, SOD 280.2±0.3E/L. Tchol, LDL were 6.24±0.14 and 4.8±0.15 mmol/l. The relation between these parameters and CA stenosis were positive(from r = 0.473, to r = 0.533). HDL 1.11±0.04 mmol/l and GPX 3423.2±1.1E/L. The correlation between HDL, GPX , CA stenosis and IMT was negative (r= - 0.433,r = - 0.401, r = - 0.452 ). In Group II, The homocystein was 24.0±0.3 mkmol/l, TAS level 2.4 ±0.03mmol/l SOD 293.1±0.4E/L, Tchol 6.97±0.04 and LDL 5.63±0.05 mmol/l. Correlation between these parameters and CA stenosis was positive( r= 0.505, r = 0.621). HDL was 0.84±0.02mmol/l, GPX 3493.1±0.7E/L. Correlation between HDL, CA stenosis and IMT was negative(r = -0.531, r = -0.491).Conclusions: Taking into consideration the result obtained, we think it is possible to use positive correlation between lipids, D dimer, homocystein, TAS and SOD, also negative correlation between HDL,GPX and the degree of CA stenosis, as the markers of development of carotid atherosclerosis in patients with carotid atherosclerosis Background and Aims : The purpose of this study were find relationship between homocysteine, total antioxidant status(TAS ), superoxide dismutase(SOD), glutation peroxidase(GPX) and lipids in patients with carotid atherosclerosis. Methods: 89 patients with ACA (age 59.4±1.7 years) were divided into 2 groups. Group I comprised 51 patients, with hemodynamically insignificant stenosis of CA (<50%) and IMT 0.95±0.04mm. Group II 38 patients with hemodynamically significant stenosis (>50%), IMT was 1.1±0.1mm. Control group 49 healthy patients. Results: In group I Correlation was positive(from r=0.500 to r=0.628). Homocysteine increased up to 17.0±0.3 mkmol/l. TAS up to 2.20±0.03mmol/l, SOD 280.2±0.3E/L. Tchol, LDL were 6.24±0.14 and 4.8±0.15 mmol/l. The relation between these parameters and CA stenosis were positive(from r = 0.473, to r = 0.533). HDL 1.11±0.04 mmol/l and GPX 3423.2±1.1E/L. The correlation between HDL, GPX , CA stenosis and IMT was negative (r= - 0.433,r = - 0.401, r = - 0.452 ). In Group II, The homocystein was 24.0±0.3 mkmol/l, TAS level 2.4 ±0.03mmol/l SOD 293.1±0.4E/L, Tchol 6.97±0.04 and LDL 5.63±0.05 mmol/l. Correlation between these parameters and CA stenosis was positive( r= 0.505, r = 0.621). HDL was 0.84±0.02mmol/l, GPX 3493.1±0.7E/L. Correlation between HDL, CA stenosis and IMT was negative(r = -0.531, r = -0.491). Conclusions: Taking into consideration the result obtained, we think it is possible to use positive correlation between lipids, D dimer, homocystein, TAS and SOD, also negative correlation between HDL,GPX and the degree of CA stenosis, as the markers of development of carotid atherosclerosis in patients with carotid atherosclerosis