Interaction between GSTM1/GSTT1 Polymorphism and Prenatal Bisphenol A Exposure on Infant Neurodevelopment at 6 Months

Abstract

Interaction between GSTM1/GSTT1 Polymorphism and Prenatal Bisphenol A Exposure on Infant Neurodevelopment at 6 MonthsAbstract Number:2279 Eun-Kyo Park*, HyeSook Park, Yun-Chul Hong, Mina Ha, Yangho Kim, Byung-Mi Kim, Eunjeong Kim, and Eun-Hee Ha Eun-Kyo Park* Department of Preventive Medicine, School of Medicine, Ewha Womans University, Korea, E-mail Address: [email protected] Search for more papers by this author , HyeSook Park Department of Preventive Medicine, School of Medicine, Ewha Womans University, Korea, E-mail Address: [email protected] Search for more papers by this author , Yun-Chul Hong Department of Preventive Medicine, College of Medicine, Seoul National University, Korea, E-mail Address: [email protected] Search for more papers by this author , Mina Ha Department of Preventive Medicine, College of Medicine, Dankook University, Korea, E-mail Address: [email protected] Search for more papers by this author , Yangho Kim Department of Occupational and Environmental Medicine, Ulsan University Hospital, Korea, E-mail Address: [email protected] Search for more papers by this author , Byung-Mi Kim Department of Preventive Medicine, School of Medicine, Ewha Womans University, Korea, E-mail Address: [email protected] Search for more papers by this author , Eunjeong Kim Department of Preventive Medicine, School of Medicine, Ewha Womans University, Korea, E-mail Address: [email protected] Search for more papers by this author , and Eun-Hee Ha Department of Preventive Medicine, School of Medicine, Ewha Womans University, Korea, E-mail Address: [email protected] Search for more papers by this author AbstractBACKGROUND : The few studies have suggested that prenatal Bisphenol A (BPA) exposure may be linked to infantile neurodevelopment. Glutathione S-transferases (GSTs) provide antioxidant defense against oxidative stress in all the vital tissues. We investigated the interaction between GSTM1/GSTT1 Polymorphism and prenatal BPA exposure on infant neurodevelopment at 6 months.METHODS : The prospective cohort study of Mothers and Children's Environmental Health (MOCEH) was built up in 2006 and the study subjects were restricted to those for whom BPA and GSTM were assessed and 575 mother–infant pairs were eligible. The total urinary concentration of BPA was measured from mothers during their late pregnancy. The Mental (MDI) and Psychomotor (PDI) Development Index scores of the infants were assessed by using the Bayley Scales of Infant Development. The genotyping of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) polymorphisms were carried out by using polymerase chain reaction. We performed a multiple linear regression model for statistical analyses (SAS 9.3).RESULTS : The BPA concentration was 1.14 ug/g creatinine in maternal urine. MDI at 6 months was inversely associated with the natural log concentrations of maternal BPA (ß=-0.0107, p=0.005). Infant neurodevelopment at 6 months decreased with increasing maternal BPA whose mothers had the either GSTT1/GSTM1 null type (ß=-0.0111, p=0.010). However, there was no significantly inverse relationship between BPA and infant neurodevelopment at 6 months in the GSTM1 and GSTT1 present genotypes.CONCLUSION : We found the association between maternal BPA exposure and infant neurodevelopment was differed by GSTT1/GSTM1 null type. ACKNOWLEDGMENT : This study was supported by MOCEH (Mothers and Children’s Environmental Health) project of the National Institute of Environmental Research, Republic of Korea.