Abstract
Using a case–control design, we assessed the association between single nucleotide polymorphisms (SNPs) of growth and differentiation factor 5 (GDF5)/rs143383 gene and interaction with environments and knee osteoarthritis (KOA). We recruited 288 KOA patients from the First Clinical College, Henan University of Chinese Medicine between June 2017 and May 2018. There was significant difference in genotype distribution between case group and control group (χ2 = 22.661, P=0.000). The minor C allele was significantly higher in the case group than that in the control group (20.5 vs 8.1%, P=0.000, odds ratio (OR) = 1.62, 95% confidence interval (CI): 1.29–2.03). Significant differences were also observed in other gene models. For age, all models show significant differences (P<0.05) for those whose age was more than 60 years, and no significant difference was observed for those under 60 years. For non-smoking group, there were significant differences between case group and control group, and for smoker, significance level was found in TT compared with CC and allele gene models. Patients with drinking and Bbody mass index (MI )≥ 24 also showed significant relationship between rs143383 and osteoarthritis (OA) under the following models: TT vs CC (P=0.000, P=0.018), TT/CT vs CC (P=0.043), TT vs CT/CC (P=0.000, P=0.009), and T vs C (P=0.024, P=0.000). Other gene models indicated no significance (P>0.05). Our results revealed a possible genetic association between GDF5 and KOA, and the TT genotype of rs143383 increased the risk of KOA in Chinese Han population. The interaction between GDF5 gene and drinking, smoking, and obesity further increased the risk of KOA.
Highlights
Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with age, and affects most individuals over the age of 65 and is a leading musculoskeletal cause of impaired mobility in the elderly [1,2]
The present study investigates the association between single nucleotide polymorphism (SNP) of growth and differentiation factor 5 (GDF5)/rs143383 gene and Knee OA (KOA) in Chinese Han population
The minor C allele was significantly higher in the case group than that in the control group (20.5 vs 8.1%, P=0.000, odds ratio (OR) = 1.62, 95% confidence interval (CI): 1.29–2.03)
Summary
Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with age, and affects most individuals over the age of 65 and is a leading musculoskeletal cause of impaired mobility in the elderly [1,2]. OA mainly affects the joints including knees, hands, hips, and spine and is a leading musculoskeletal cause of impaired mobility in the elderly. Several risk factors associated with KOA have been put forward, including a genetic predisposition, ageing, obesity, dieting, and joint malalignment, the pathogenesis of KOA remains largely unclear [7,8,9,10,11,12]. The variations in genetic susceptibility in different ethnic groups has led us to attempt to examine the association between GDF5 gene polymorphism (rs143383) and KOA. There is no report about the relationship between GDF5/rs143383 gene and KOA. The present study investigates the association between SNPs of GDF5/rs143383 gene and KOA in Chinese Han population
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