INTERACTION BETWEEN FK506 AND CLOTRIMAZOLE IN A LIVER TRANSPLANT RECIPIENT

Abstract

FK506, a new and powerful immunosuppressant, has become the principal drug in the immunosuppressive regimens of organ transplant recipients at the University of Pittsburgh (1–3). It is well known that transplant patients often receive multiple-drug therapy, and that many of these co-administered agents can alter the kinetics of immunosuppressive drugs, such as cyclosporine and prednisone (4,5). In this communication we report for the first time a potential interaction between FK506 and the antifungal agent clotrimazole in a liver transplant recipient.