Abstract
This chapter discusses the interaction between catecholamines and thyroid hormones in regulation of exercise metabolism in dogs. The lipolytic effect of catecholamines in vitro is markedly increased in subcutaneous adipose tissue from thyroid hormone treated the animals and reverse has been found in hypothyroid subjects. Studies have shown that a single injection of triiodothyronine (T3) or thyroxine (T4) to normal dogs results in enhanced lipid mobilization and increased body temperature (Tre) during exercise-stress, although at rest plasma free fatty acid (PFA) concentration and (Tre) were not elevated above the control values. It was demonstrated that during physical effort, a marked rise in blood level of catecholamines occurs. The present study was undertaken to ascertain the role of catecholamines in the thyroid hormone-induced changes of metabolism and body temperature during exercise in dogs. For this purpose propranolol, which inhibits the metabolic action of catecholamines, was administered before or during physical effort performed by thyroxine treated dogs.
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